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Oxidative stress of brain and liver is increased by Wi-Fi (2.45 GHz) exposure
28 okt. 2015
Journal of Chemical Neuroanatomy
Oxidative stress of brain and liver is increased by Wi-Fi (2.45 GHz) exposure of rats during pregnancy and the development of newborns
Ömer Çelik1, 2, , , Mehmet Cemal Kahya3, , , Mustafa Nazıroğlu1, 2
1 Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey
2 Department of Biophysics, Medicine Faculty, Suleyman Demirel University, Isparta, Turkey
3 Department of Biophysics, Medicine Faculty, Izmir Katip Celebi University, Izmir, Turkey
Received 22 September 2015, Revised 15 October 2015, Accepted 16 October 2015, Available online 28 October 2015
Oxidative stress plays important role in biology of Wi-Fi (2.45 GHz)> 2.45 GHz increased oxidative stress in brain and liver pregnant rats and their newborns.> Brain seems sensitive to oxidative injury in the development of newborns.
An excessive production of reactive oxygen substances (ROS) and reduced antioxidant defence systems resulting from electromagnetic radiation (EMR) exposure may lead to oxidative brain and liver damage and degradation of membranes during pregnancy and development of rat pups. We aimed to investigate the effects of Wi-Fi-induced EMR on the brain and liver antioxidant redox systems in the rat during pregnancy and development.
Sixteen pregnant rats and their 48 newborns were equally divided into control and EMR groups. The EMR groups were exposed to 2.45 GHz EMR (1 hour/day for 5 days/week) from pregnancy to 3 weeks of age. Brain cortex and liver samples were taken from the newborns between the first and third weeks. In the EMR groups, lipid peroxidation levels in the brain and liver were increased following EMR exposure; however, the glutathione peroxidase (GSH-Px) activity, and vitamin A, vitamin E and -carotene concentrations were decreased in the brain and liver. Glutathione (GSH) and vitamin C concentrations in the brain were also lower in the EMR groups than in the controls; however, their concentrations did not change in the liver.
In conclusion, Wi-Fi-induced oxidative stress in the brain and liver of developing rats was the result of reduced GSH-Px, GSH and antioxidant vitamin concentrations. Moreover, the brain seemed to be more sensitive to oxidative injury compared to the liver in the development of newborns.
EMR, electromagnetic radiation; GSH, glutathione; GSH-Px, glutathione peroxidase; LP, lipid peroxidation; PUFAs, polyunsaturated fatty acids; ROS, reactive oxygen species; SAR, specific absorption rate
Brain; Electromagnetic radiation; Glutathione; Liver; Oxidative stress; Antioxidant vitamins.
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