OXIDATIVE MECHANISMS of biological activity of low-intensity radiofrequency radiation

Bron 1: www.tandfonline.com/doi/abs/10.3109/15368378.2015.1043557
7 juli 2015
www.ncbi.nlm.nih.gov/pubmed/26151230
Electromagn Biol Med. 2016;35(2):186-202. doi: 10.3109/15368378.2015.1043557. Epub 2015 Jul 7.

Review Article

Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation

Posted online on July 7, 2015. (doi:10.3109/15368378.2015.1043557)

Igor Yakymenko 1, Olexandr Tsybulin 2, Evgeniy Sidorik 1, Diane Henshel 3, Olga Kyrylenko 4, and Sergiy Kyrylenko 5

1 Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv, Ukraine,
2 Department of Biophysics, Bila Tserkva National Agrarian University, Bila Tserkva, Ukraine,
3 School of Public and Environmental Affairs, Indiana University Bloomington, Bloomington, IN, USA,
4A. I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland, and
5 Department of Structural and Functional Biology, University of Campinas, Campinas, SP, Brazil

Address correspondence to Prof. Igor Yakymenko, Laboratory of Biophysics, Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Vasylkivska str. 45, Kyiv, 03022 Ukraine. E-mail: iyakymen@gmail.com

Abstract

This review aims to cover experimental data on oxidative effects of low-intensity radiofrequency radiation (RFR) in living cells. Analysis of the currently available peer-reviewed scientific literature reveals molecular effects induced by low-intensity RFR in living cells; this includes significant activation of key pathways generating reactive oxygen species (ROS), activation of peroxidation, oxidative damage of DNA and changes in the activity of antioxidant enzymes. It indicates that among 100 currently available peer-reviewed studies dealing with oxidative effects of low-intensity RFR, in general, 93 confirmed that RFR induces oxidative effects in biological systems. A wide pathogenic potential of the induced ROS and their involvement in cell signaling pathways explains a range of biological/health effects of low-intensity RFR, which include both cancer and non-cancer pathologies. In conclusion, our analysis demonstrates that low-intensity RFR is an expressive oxidative agent for living cells with a high pathogenic potential and that the oxidative stress induced by RFR exposure should be recognized as one of the primary mechanisms of the biological activity of this kind of radiation.

Keywords

Cellular signaling, cancer, free radicals, oxidative stress, radiofrequency radiation, reactive oxygen species

Bron 2: www.news-medical.net/news/20150725/Metabolic-imbalance-caused-by-radiation-from-wireless-devices-linked-to-many-health-risks.aspx
29 juli 2015

Metabolic imbalance caused by radiation from wireless devices linked to many health risks

A metabolic imbalance caused by radiation from your wireless devices could be the link to a number of health risks, such as various neurodegenerative diseases and cancer, a recent study suggests.

''Oxidative Mechanisms of Biological Activity of Low-intensity Radiofrequency Radiation,'' a review article published in Electromagnetic Biology & Medicine, explores experimental data on the metabolic effects of low-intensity radiofrequency radiation in living cells.

This imbalance, also known as oxidative stress, is defined by co-author Dr. Igor Yakymenko as, ''an imbalance between the production of reactive oxygen species (ROS) and antioxidant defence.''

Yakymenko explains the oxidative stress due to RFR exposure could explain not only cancer, but also other minor disorders such as headache, fatigue, and skin irritation, which could develop after long-term RFR exposure.

''These data are a clear sign of the real risks this kind of radiation poses for human health,'' Yakymenko said.

The article explains that ROS are often produced in cells due to aggressive environments, and can also be provoked by ''ordinary wireless radiation.''

Up-to-date research demonstrates possible carcinogenic effects of radiofrequency (RFR)/microwave radiation. In 2011, the International Agency for Research on Cancer classified RFR as a possible carcinogen for humans. But clear molecular mechanisms of such effects of RFR were a bottleneck in acceptance of a reality of risk.

The article demonstrates that the hazardous effects of RFR could be realized through the ''classical mechanisms'' of oxidative impairments in living cells.

Yakymenko and his colleagues call for a precautionary approach in using wireless technologies, such as cell phones and wireless Internet.

Zie ook:
www.nydailynews.com/life-style/health/cellphone-radiation-cancer-study-article-1.2308509
29 juli 2015
Hold the phone, Central! Cellphone radiation can cause cancer: study



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