Cognitive Impairment and Neurogenotoxic Effects in Rats Exposed to Low-Intensity Microwave Radiation

Bron: ijt.sagepub.com/content/34/3/284.abstract .
27 mei 2015

International Journal of Toxicology

Pravin Suryakantrao Deshmukh1
Namita Nasare1,2
Kanu Megha1
Basu Dev Banerjee1⇑
Rafat Sultana Ahmed1
Digvijay Singh1
Mahesh Pandurang Abegaonkar3
Ashok Kumar Tripathi1
Pramod Kumari Mediratta2

1Department of Biochemistry, Environmental Biochemistry and Molecular Biology Laboratory, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi, India
2Department of Pharmacology, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi, India
3Centre for Applied Research in Electronics (CARE), Indian Institute of Technology, Hauz Khas, New Delhi, India

Basu Dev Banerjee, Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110095, India. Email: banerjeebd@hotmail.com

Abstract

The health hazard of microwave radiation (MWR) has become a recent subject of interest as a result of the enormous increase in mobile phone usage. The present study aimed to investigate the effects of chronic low-intensity microwave exposure on cognitive function, heat shock protein 70 (HSP70), and DNA damage in rat brain. Experiments were performed on male Fischer rats exposed to MWR for 180 days at 3 different frequencies, namely, 900, 1800 MHz, and 2450 MHz. Animals were divided into 4 groups: group I: sham exposed; group II: exposed to MWR at 900 MHz, specific absorption rate (SAR) 5.953 × 10−4 W/kg; group III: exposed to 1800 MHz, SAR 5.835×10−4 W/kg; and group IV: exposed to 2450 MHz, SAR 6.672 × 10−4 W/kg. All the rats were tested for cognitive function at the end of the exposure period and were subsequently sacrificed to collect brain. Level of HSP70 was estimated by enzyme-linked immunotarget assay and DNA damage was assessed using alkaline comet assay in all the groups. The results showed declined cognitive function, elevated HSP70 level, and DNA damage in the brain of microwave-exposed animals. The results indicated that, chronic low-intensity microwave exposure in the frequency range of 900 to 2450 MHz may cause hazardous effects on the brain.



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