Magnetic fields exposure and childhood leukemia risk

Bron: www.lrjournal.com/article/S0145-2126(13)00427-X/abstract .
en
www.ncbi.nlm.nih.gov/pubmed/24388073?dopt=Abstract .
2 jan. 2014

Article in Press
Magnetic fields exposure and childhood leukemia risk: A meta-analysis based on 11,699 cases and 13,194 controls

Longyu Zhao, Xiaodong Liu, Chunpeng Wang, Kangkang Yan, Xuejun Lin, Shuang Li, Honghong Bao, Xin Liue
Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, China

Abstract

Objective
To observe the association between childhood leukemia and magnetic field exposure.

Methods
The literature was searched by PubMed, ProQuest, Web of Science (SCI) and Medline databases during 1997–2013. Heterogeneity in several studies was weighted by I-squared value. Publication bias was tested by funnel plot and Egger's test. Odds ratio (OR) and 95% CI were used to evaluate the association strength. The statistical analyses in present study were carried out by STATA software package (version 12.0, College Station, TX).

Results
A total of 11,699 cases and 13,194 controls in 9 studies were stratified by different exposure cut-off points. On condition of the reference <0.1μT, statistical association between magnetic field intensity ≥0.4μT and childhood leukemia was exhibited (for total leukemia: OR=1.57, 95% CI=1.03–2.40; for acute lymphocytic leukemia: OR=2.43, 95% CI=1.30–4.55). On condition of the reference level of <0.2μT, the positive association between magnetic field intensity ≥0.2μT and childhood leukemia was found (OR=1.31, 95% CI=1.06–1.61).

Conclusions
The result in this meta-analysis indicated that magnetic field exposure level may be associated with childhood leukemia.

Keywords: Magnetic field, Childhood, Leukemia, Meta-analysis, Risk



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