Iran/Saudi-Arabia: Schade aan ogen en testes bij ratten. Prophylactische werking vitamine C.
vrijdag, 17 augustus 2012 - Categorie: Onderzoeken
Bron: International Journal of Radiation Biology 2012 Aug 15.
The prophylactic Effect of Vitamin C on Oxidative Stress Indexes in Rat Eyes Following Exposure to Radiofrequency Wave Generated by a BTS Antenna Model.
Jelodar G, Akbari A, Nazifi S.
This study was conducted to evaluate the effect of radiofrequency wave (RFW)-induced oxidative stress in the eye and the prophylactic effect of vitamin C on this organ by measuring the antioxidant enzymes activity including: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA).
Materials and methods:
Thirty-two adult male Sprague-Dawley rats were randomly divided into four experimental groups and treated daily for 45 days as follows: control, vitamin C (L-ascorbic acid 200 mg/kg of body weight/day by gavage), test (exposed to 900 MHz RFW) and the treated group (received vitamin C in addition to exposure to RFW). At the end of the experiment all animals were killed, their eyes were removed and were used for measurement of antioxidant enzymes and MDA activity.
The results indicate that exposure to RFW in the test group decreased antioxidant enzymes activity and increased MDA compared with the control groups (P<0.05). In the treated group vitamin C improved antioxidant enzymes activity and reduced MDA compared to the test group (P<0.05).
It can be concluded that RFW causes oxidative stress in the eyes and vitamin C improves the antioxidant enzymes activity and decreases MDA
Voor het originele abstract zie:
Bron: Clinics (Sao Paulo). 2012 Jul;67(7):785-92.
Rat testicular impairment induced by electromagnetic radiation from a conventional cellular telephone and the protective effects of the antioxidants vitamins C and E.
Department of Biology, College of Science and Arts, Qassim University, Saudi Arabia.
The aim of this study was to investigate the possible effects of electromagnetic radiation from conventional cellular phone use on the oxidant and antioxidant status in rat blood and testicular tissue and determine the possible protective role of vitamins C and E in preventing the detrimental effects of electromagnetic radiation on the testes.
MATERIALS AND METHODS:
The treatment groups were exposed to an electromagnetic field, electromagnetic field plus vitamin C (40 mg/kg/day) or electromagnetic field plus vitamin E (2.7 mg/kg/day). All groups were exposed to the same electromagnetic frequency for 15, 30, and 60 min daily for two weeks.
There was a significant increase in the diameter of the seminiferous tubules with a disorganized seminiferous tubule sperm cycle interruption in the electromagnetism-exposed group. The serum and testicular tissue conjugated diene, lipid hydroperoxide, and catalase activities increased 3-fold, whereas the total serum and testicular tissue glutathione and glutathione peroxidase levels decreased 3-5 fold in the electromagnetism-exposed animals.
Our results indicate that the adverse effect of the generated electromagnetic frequency had a negative impact on testicular architecture and enzymatic activity. This finding also indicated the possible role of vitamins C and E in mitigating the oxidative stress imposed on the testes and restoring normality to the testes.
Voor dit abstract zie:
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