Interphone bevestigt opnieuw: Hoger hersentumorrisico bij veelbellers.

dinsdag, 10 januari 2012 - Categorie: Onderzoeken

Bron: British Medical Journal 6 jan. 2012

Risk of brain tumours in relation to estimated RF dose
from mobile phones: results from five Interphone countries

E Cardis,1 B K Armstrong,2 J D Bowman,3 G G Giles,4,5 M Hours,6 D Krewski,7
M McBride,8 M E Parent,9 S Sadetzki,10,11 A Woodward,12 J Brown,2 A Chetrit,10
J Figuerola,1 C Hoffmann,11,13 A Jarus-Hakak,10 L Montestruq,6 L Nadon,9
L Richardson,14 R Villegas,1 M Vrijheid1


The objective of this study was to examine
the associations of brain tumours with radio frequency
(RF) fields from mobile phones.

Patients with brain tumour from the
Australian, Canadian, French, Israeli and New Zealand
components of the Interphone Study, whose tumours
were localised by neuroradiologists, were analysed.
Controls were matched on age, sex and region and
allocated the ‘tumour location’ of their matched case.
Analyses included 553 glioma and 676 meningioma
cases and 1762 and 1911 controls, respectively. RF dose
was estimated as total cumulative specific energy
(TCSE; J/kg) absorbed at the tumour’s estimated centre
taking into account multiple RF exposure determinants.

ORs with ever having been a regular mobile
phone user were 0.93 (95% CI 0.73 to 1.18) for glioma
and 0.80 (95% CI 0.66 to 0.96) for meningioma. ORs for
glioma were below 1 in the first four quintiles of TCSE
but above 1 in the highest quintile, 1.35 (95% CI 0.96 to
1.90). The OR increased with increasing TCSE 7+ years
before diagnosis (p-trend 0.01; OR 1.91, 95% CI 1.05 to
3.47 in the highest quintile). A complementary analysis in
which 44 glioma and 135 meningioma cases in the most
exposed area of the brain were compared with gliomas
and meningiomas located elsewhere in the brain showed
increased ORs for tumours in the most exposed part of
the brain in those with 10+ years of mobile phone use
(OR 2.80, 95% CI 1.13 to 6.94 for glioma). Patterns for
meningioma were similar, but ORs were lower, many
below 1.0.

There were suggestions of an increased
risk of glioma in long-term mobile phone users with high
RF exposure and of similar, but apparently much smaller,
increases in meningioma risk.
The uncertainty of these
results requires that they be replicated before a causal
interpretation can be made.

Voor het originele abstract en een PDF van de volledige studie zie: .

Voor een deskundig Engelstalig commentaar zie: .

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