Australië: Toenemend aantal kwaadaardige hersentumoren periode 2000-2008, vooral na 2006.
vrijdag, 30 december 2011 - Categorie: Onderzoeken
Bron: Surgery Neurology International 2011, 2:176 DOI: 10.4103/2152-7806.90696
Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): Findings of a multicenter Australian study
Martin Dobes1, Vini G Khurana1, Bruce Shadbolt2, Sanjiv Jain3, Sarah F Smith4, Robert Smee5, Mark Dexter6, Raymond Cook4
1 Medical School, Australian National University; Department of Neurosurgery, Canberra Hospital, Canberra, Australia
2 Medical School, Australian National University; Epidemiology Unit, Canberra Hospital, Canberra, Australia
3 Medical School, Australian National University; Department of Pathology, Canberra Hospital, Canberra, Australia
4 Department of Cancer Services, Royal North Shore Hospital, Sydney, Australia
5 Department of Radiation Oncology, Prince of Wales Hospital, Sydney, Australia
6 Department of Neurosurgery, Children's Hospital at Westmead, Sydney, Australia
Vini G Khurana
Medical School, Australian National University; Department of Neurosurgery, Canberra Hospital, Canberra
The incidence of primary brain tumors by subtype is currently unknown in Australia. We report an analysis of incidence by tumor subtype in a retrospective multicenter study in the state of New South Wales (NSW) and the Australian Capital Territory (ACT), with a combined population of >7 million with >97% retention rate for medical care.
Data from histologically confirmed primary brain tumors diagnosed from January 2000 through December 2008 were weighted for patient outflow and data completeness, and age standardized and analyzed using joinpoint analysis.
Results: A significant increasing incidence in glioblastoma multiforme (GBM) was observed in the study period (annual percentage change APC, 2.5; 95% confidence interval CI, 0.4-4.6, n = 2275), particularly after 2006. In GBM patients in the ≥65-year group, a significantly increasing incidence for men and women combined (APC, 3.0; 95% CI, 0.5-5.6) and men only (APC, 2.9; 95% CI, 0.1-5.8) was seen. Rising trends in incidence were also seen for meningioma in the total male population (APC, 5.3; 95% CI, 2.6-8.1, n = 515) and males aged 20-64 years (APC, 6.3; 95% CI, 3.8-8.8). Significantly decreasing incidence trends were observed for Schwannoma for the total study population (APC, −3.5; 95% CI, −7.2 to −0.2, n = 492), significant in women (APC, −5.3; 95% CI, −9.9 to −0.5) but not men.
This collection is the most contemporary data on primary brain tumor incidence in Australia. Our registries may observe an increase in malignant tumors in the next few years that they are not detecting now due to late ascertainment. We recommend a direct, uniform, and centralized approach to monitoring primary brain tumor incidence by subtype, including the introduction of nonmalignant data collection.
Voor het volledige artikel met figuren en hyperlinks zie:
Lees verder in de categorie Onderzoeken | Terug naar homepage | Lees de introductie