Zweedse onderzoeker voorspelt een pandemie aan hersentumoren in de toekomst.
woensdag, 28 december 2011 - Categorie: Onderzoeken
Gerelateerd bericht: Artikelen/3904
Bron: Journal of Neurology & Neurophysiology 2011, Brain Tumor 2155-9562 JNN,
The Potential Impact of Mobile Phone Use on Trends in Brain and CNS
Örjan Hallberg1* and L Lloyd Morgan2
1Hallberg Independent Research, Brattforsgatan 3, 123 50 Farsta, Sweden
2Environmental Health Trust, 2022 Francisco Street, Berkeley, CA 94709, USA
Case-control studies have reported an increased risk of brain tumors after 10 or more years of cell phone use.
To model brain cancer trends by extracting characteristic risk functions from reported data and to use these for projecting future trends accounting for possible influences from mobile phone use.
Normally occurring DNA brain cell damage during one year was assumed to be associated with a cancer risk function that is increasing over time but balanced by a DNA repair function reducing the amount of potential carcinogen damages over time. By model parameter adjustments of risk functions, calculated age-adjusted
rates were made to best fit the reported data. The model also accounted for increasing levels of initial DNA brain damage or decreasing repair efficiency, caused by cell phone use.
DNA brain cell damage has an average latency time of over 30 years before increased brain cancer rates would be expected. Mobile phone use may lead to a reduced DNA repair function resulting in about a 2-fold increase in brain cancer incidence, or with an increasing rate of initial DNA brain damage from mobile phone use a 25-fold increase in brain cancer incidence may result.
Voor het volledige zeer interessante artikel met figuren (8 pp) zie:
Press Release: Brain Tumor Pandemic-DNA Impacts from Mobile Phones Implicated in New Analysis
December 24, 2011, Berkeley, CA, USA & Stockholm, Sweden.
An important new analysis, The Potential Impact of Mobile Phone Use on Trends in Brain and CNS Tumors, was published today in the journal Neurology & Neurophysiology. It can be downloaded without cost athttp://www.omicsonline.org/2155-9562/2155-9562-S5-003.pdf. The paper is in a Special Issue of the journal titled “Brain Tumor.”
The study raises very serious concerns about the potential for a large increase in brain cancer incidence, resulting from widespread mobile phone use. The steep increase in brain cancer will begin in approximately 15 years according to the projections.
The paper, by researchers Örjan Hallberg in Sweden and L. Lloyd Morgan in the U.S., first reviews biological effects from mobile phone use reported in peer-reviewed studies, such as increased permeability of the blood-brain barrier, deleterious effects on sperm, double strand breaks in DNA, stress gene activation (indicating an exposure to a toxin), and increased risk of an acoustic nerve tumor (acoustic neuroma) and brain cancer after 10 or more years of mobile phone use. It then considered two established mechanisms for the development of brain cancer—that mobile phone use decreases the efficiency of the repair of mutated DNA and that mobile phone use increases the rate of DNA mutations.
In developing the model from brain cancer registry data, mathematical model parameters are selected which provide a best fit to the age adjusted registry data. The model can be considered reasonably accurate if it approximates both the age-specific brain cancer incidence (e.g., 30-34 year age cohort) and the age-adjusted brain cancer incidence from the cancer registry data. It can then be used by the researchers to predict future brain cancer incidence.
Based on a 30-year time between first mobile phone use and diagnoses of brain cancer (latency time), the model predicts that there will be a 100% increased incidence of brain cancer (2-fold) if DNA repair efficiency is decreased by mobile phone use, and a 2,400% increase in brain tumors (25-fold) if mobile phone use mutates DNA. The figure below, from the paper illustrates these predictions.
Figure 3. Norwegian brain tumor age-adjusted rates per 100,000 person-years by calendar year for reported data with 3 results from mobile phone use 1) Increased DNA damage 2) no DNA repair and 3) has no effect.
The public health risk modeling process used in this analysis was developed by Örjan Hallberg and has been successfully applied in other illnesses, including Alzheimer’s disease and melanoma.
Hallberg says, “Such modeling, or risk projection, is important, whether for the climate or for diseases, in that it allows public health contingency planning, should the model be reasonable accurate. For example, will there be sufficient neurosurgeons should brain tumors increase as the model predicts?”
Morgan says, “What this analysis shows is that, unless mobile phone usage behavior patterns change significantly, we can reasonably expect a pandemic of brain tumors, for which we are ill-prepared, beginning approximately 15 years from now. Governments, as well as parents, physicians, schools and all citizens, would be well advised to educate all persons under their care or influence about the need to curtail the use of mobile phones and other radiation-emitting consumer devices.”
Europe: Örjan Hallberg in Sweden
firstname.lastname@example.org,">(email@example.com, + 46 (8) 605 4998).
North America: Lloyd Morgan in Berkeley, California, USA
Sr. Research Fellow, Environmental Health Trust
Lloyd.L.Morgan@gmail.com,">(Lloyd.L.Morgan@gmail.com, +510 841-4362).
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