Intenationaal onderzoek over het risico op hersentumoren en mobiele telefonie.

Wetenschappers uit vijf verschillende landen namen deel aan dit onderzoek, dat ten grondslag ligt aan de opzienbarende koerswijziging van de WHO.
De onderzoekers Cardis en Sadetzki zochten met waarschuwingen reeds eerder de publiciteit, zie Onderzoeken/5452 .

Occupational and Environmental Medicine 9 juni 2011 doi:10.1136/oemed-2011-100155

Original article
Risk of brain tumours in relation to estimated RF dose from mobile phones: results from five Interphone countries

E Cardis1, B K Armstrong2, J D Bowman3, G G Giles4,5, M Hours6, D Krewski7, M McBride8, M E Parent9, S Sadetzki10,11, A Woodward12, J Brown2, A Chetrit10, J Figuerola1, C Hoffmann11,13, A Jarus-Hakak10, L Montestruq6, L Nadon9, L Richardson14, R Villegas1, M Vrijheid1
+ Author Affiliations

1 Centre for Research in Environmental Epidemiology (CREAL), Hospital del Mar Research Institute (IMIM), CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain
2 Sydney School of Public Health, The University of Sydney, Sydney, Australia
3 Engineering and Physical Hazards Branch, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA
4 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
5 Centre for MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
6 Université de Lyon, Institut français des sciences et technologies des transports, de l'aménagement et des réseaux, Institut national de Veille Sanitaire, Unité Mixte de Recherche épidémiologique et de Surveillance Transports Travail Environnement, Lyon, France
7 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada
8 BC Cancer Research Centre, BC Cancer Agency, Vancouver, Canada
9 INRS-Institut Armand-Frappier, Université du Québec, Laval, Canada
10 Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel
11 Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
12 School of Population Health, University of Auckland, Auckland, New Zealand
13 Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Israel
14 Department of Population health, Hospital Research Centre (CRCHUM) University of Montreal, Montreal, Canada

Correspondence to
Professor E Cardis, Centre for Research in Environmental Epidemiology (CREAL), Hospital del Mar Research Institute (IMIM), CIBER Epidemiologia y Salud Pública (CIBERESP), Doctor Aiguader 88, 08003 Barcelona, Spain;
ecardis@creal.cat

Contributors All authors participated in the conception and design, analysis and interpretation of data, the drafting of the article or its critical revision for important intellectual content and approved the version to be published.

Abstract
Objectives The objective of this study was to examine the associations of brain tumours with radio frequency (RF) fields from mobile phones.

Methods
Patients with brain tumour from the Australian, Canadian, French, Israeli and New Zealand components of the Interphone Study, whose tumours were localised by neuroradiologists, were analysed. Controls were matched on age, sex and region and allocated the ‘tumour location’ of their matched case. Analyses included 553 glioma and 676 meningioma cases and 1762 and 1911 controls, respectively. RF dose was estimated as total cumulative specific energy (TCSE; J/kg) absorbed at the tumour's estimated centre taking into account multiple RF exposure determinants.

Results
ORs with ever having been a regular mobile phone user were 0.93 (95% CI 0.73 to 1.18) for glioma and 0.80 (95% CI 0.66 to 0.96) for meningioma. ORs for glioma were below 1 in the first four quintiles of TCSE but above 1 in the highest quintile, 1.35 (95% CI 0.96 to 1.90). The OR increased with increasing TCSE 7+ years before diagnosis (p-trend 0.01; OR 1.91, 95% CI 1.05 to 3.47 in the highest quintile). A complementary analysis in which 44 glioma and 135 meningioma cases in the most exposed area of the brain were compared with gliomas and meningiomas located elsewhere in the brain showed increased ORs for tumours in the most exposed part of the brain in those with 10+ years of mobile phone use (OR 2.80, 95% CI 1.13 to 6.94 for glioma). Patterns for meningioma were similar, but ORs were lower, many below 1.0.

Conclusions
There were suggestions of an increased risk of glioma in long-term mobile phone users with high RF exposure and of similar, but apparently much smaller, increases in meningioma risk. The uncertainty of these results requires that they be replicated before a causal interpretation can be made.

Voor het originele abstract zie:
oem.bmj.com/content/early/2011/06/09/oemed-2011-100155.abstract .

Lees verder in de categorie Onderzoeken | Terug naar homepage | Lees de introductie