Dubbele DNA breuken in hersencellen van ratten bij blootstelling aan 2450 MHz straling

Int J Radiat Biol. 1996 Apr;69(4):513-21. Related Articles, Links

Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation.

Lai H, Singh NP.

Bioelectromagetics Research Laboratory, Center for Bioengineering, University of Washington, Seattle, 98195, USA.

Korte Nederlandstalige samenvatting
Hersencellen van ratten, blootgesteld aan zowel gepulste als ongepulste straling van 2450 MHz, werden na de blootstelling onderzocht op schade aan het genetische materiaal (het DNA). SAR waarde was 1,2 W/kg. Enkele en dubbele DNA breuken werden vastgesteld na 2 uur blootstelling, zowel bij de gepulste als bij de ongepulste straling. Dit bevestigt eerder gedane studies, zowel in-vitro als in-vivo, die ook effecten vonden op het genetische materiaal door blootstelling aan hoogfrequente straling.

Abstract
We investigated the effects of acute (2-h) exposure to pulsed (2-micros pulse width, 500 pulses s(-1)) and continuous wave 2450-MHz radiofrequency electromagnetic radiation on DNA strand breaks in brain cells of rat. The spatial averaged power density of the radiation was 2mW/cm2, which produced a whole-body average-specific absorption rate of 1.2W/kg. Single- and double-strand DNA breaks in individual brain cells were measured at 4h post-exposure using a microgel electrophoresis assay. An increase in both types of DNA strand breaks was observed after exposure to either the pulsed or continuous-wave radiation, No significant difference was observed between the effects of the two forms of radiation. We speculate that these effects could result from a direct effect of radiofrequency electromagnetic energy on DNA molecules and/or impairment of DNA-damage repair mechanisms in brain cells. Our data further support the results of earlier in vitro and in vivo studies showing effects of radiofrequency electromagnetic radiation on DNA.

PMID: 8627134 PubMed - indexed for MEDLINE



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