India: Genetische veranderingen bij ratten na blootstelling aan microwaves.

Bron: Indian Journal of Experimental Biology 2010; 48 (6): 586 - 592

Evaluation of genotoxic effects in male Wistar rats following microwave exposure. med./biol.

Auteurs: Kumar S, Kesari KK, Behari J

Aim of study (according to author)
To study the effects of microwave exposure on micronuclei formation and antioxidant enzymatic system in adult male rats.

Background/further details:
24 rats were divided into two different exposure groups and two different sham exposure groups (each group n=6).

Endpoint:
micronuclei formation, reactive oxygen species production and antioxidant defense

Exposure General category: microwaves

Field characteristics Parameters
field 1: 10 GHz
exposure duration: continuous for 2 hr/day on 45 days power flux density: 0.214 mW/cm² SAR: 0.014 W/kg

field 2: 50 GHz
exposure duration: continuous for 2 hr/day on 45 days power flux density: 0.86 µW/cm² SAR: 0.8 mW/kg

Exposed system:
animal (species/strain): rat/Wistar whole body exposure

Methods
Endpoint/Measurement parameters/Methodology

genotoxicity/mutation: micronuclei formation in polychromatic erythrocytes and normochromatic erythrocytes (acridine orange staining; flow cytometry)

molecular biosynthesis: serum reactive oxygen species production (spectrophotometry)

cell function: antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase and catalase; spectrophotometry)

investigated material: intact cell/cell culture (in vitro), blood samples and cell supernatants
investigated organ system: immune system

time of investigation: after exposure

Main outcome of study (according to author)
The data showed that microwave exposure induced micronuclei formation and a significant increase in reactive oxygen species production (both more pronounced at 50 GHz). Significant changes in the enzyme activities of serum glutathione peroxidase (decrease), superoxide dismutase (decrease) and catalase (increase) were observed in exposed group as compared with control group.

The authors conclude that microwave exposure can be effective at genetic level.

Study funded by
Council of Scientific and Industrial Research (CSIR), New Delhi, India
Indian Council of Medical Research (ICMR), India

Voor het volledige artikel zie:
nopr.niscair.res.in/bitstream/123456789/9081/1/IJEB%2048%286%29%20586-592.pdf .



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