USA/Korea: Meta-analyse toont wederom aanwijzingen verhoogd hersentumorrisico bij >10 jaar bellen
donderdag, 15 oktober 2009 - Categorie: Onderzoeken
Gerelateerd artikel: Berichten%20Internationaal/4123
Early Release, published online ahead of print Oct 13 2009
Bron: Journal of Clinical Oncology, 10.1200/JCO.2008.21.6366
Received December 19, 2008
Accepted June 9, 2009
Mobile Phone Use and Risk of Tumors: A Meta-Analysis
Seung-Kwon Myung,* Woong Ju, Diana D. McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, and Joel M. Moskowitz
From the Smoking Cessation Clinic, Center for Cancer Prevention and Detection; Division of Cancer Prevention, National Cancer Control Research Institute, National Cancer Center, Goyang; Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University; Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea; and Center for Family and Community Health, School of Public Health, University of California, Berkeley, Berkeley, CA.
Purpose: Case-control studies have reported inconsistent findings regarding the association between mobile phone use and tumor risk. We investigated these associations using a meta-analysis.
Methods: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in August 2008. Two evaluators independently reviewed and selected articles based on predetermined selection criteria.
Results: Of 465 articles meeting our initial criteria, 23 case-control studies, which involved 37,916 participants (12,344 patient cases and 25,572 controls), were included in the final analyses. Compared with never or rarely having used a mobile phone, the odds ratio for overall use was 0.98 for malignant and benign tumors (95% CI, 0.89 to 1.07) in a random-effects meta-analysis of all 23 studies.
However, a significant positive association (harmful effect) was observed in a random-effects meta-analysis of eight studies using blinding, whereas a significant negative association (protective effect) was observed in a fixed-effects meta-analysis of 15 studies not using blinding.
Mobile phone use of 10 years or longer was associated with a risk of tumors in 13 studies reporting this association (odds ratio = 1.18; 95% CI, 1.04 to 1.34). Further, these findings were also observed in the subgroup analyses by methodologic quality of study. Blinding and methodologic quality of study were strongly associated with the research group.
Conclusion: The current study found that there is possible evidence linking mobile phone use to an increased risk of tumors from a meta-analysis of low-biased case-control studies Prospective cohort studies providing a higher level of evidence are needed.
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