Gepulste straling van mobiele telefonie veroorzaakt cellulaire stress en pijn.

Een wat ouder maar interessant onderzoek in 2006 gepubliceerd in het Jounal of Pain. De intensiteit van de straling is niet vermeld, wel is duidelijk dat het effect niet-thermisch was: pijn.

Bron: European Journal of Pain, Volume 10, Issue 2, Pages 171-176 (february 2006)

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Pulsed radiofrequency applied to dorsal root
ganglia causes a selective increase in ATF3 in small neurons

W.Hamann, S.Abou-Sherif, S.Thompson, S.Hall

Abstract
Background

This is a ''proof of concept study'' to test the
hypothesis that pulsed radiofrequency, PRF,
produces cell stress at the primary afferent
level without signs of overt thermal damage. We
assumed that cell stress would result in
impairment of normal function, and used the
expression of activating transcription factor 3,
ATF3, as an indicator of cellular ''stress''.

Methods

PRF (20ms of 500-kHz RF pulses, delivered at a
rate of 2Hz; maximum temperature 42°C) was
delivered either to the sciatic nerve of adult
rats in mid thigh, or to the L4 anterior primary
ramus just distal to the intervertebral foramen.
Controls were sham-operated or L4 axotomised. All
tissues were examined 14 days after surgery. The
percentage of CGRP- or ATF3-positive DRG neuronal
somata was calculated using image analysis software (SigmaScan Pro 4).

Results

ATF3 expression was upregulated in L4 DRG
neuronal cell bodies, irrespective of their size,
after axotomy. It was also upregulated
significantly (p<0.002) and selectively, in small
and medium calibre L4 DRG neurons, when PRF was
applied close to the DRG just distal to the
intervertebral foramen. PRF did not produce any
obvious cellular changes in the nerve or L4 DRG
neurons when applied to the sciatic nerve in mid-thigh.

Conclusion

PRF has a biological effect, unlikely to be
related to overt thermal damage. It appears to be
selective in that it targets the group of neurons
whose axons are the small diameter C and Ad nociceptive fibres.

En in onderstaand onderzoek worden radiofrequente velden gebruikt om pijn te bestrijden door weefsel thermisch te vernietigen. Hoe cynisch. Niet-thermisch krijgen sommige mensen pijn, als je de intensiteit dan nog verhoogt voelen ze maandenlang geen pijn meer:

www.painphysicianjournal.com/2006/july/2006;9;227-236.pdf .



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