Exposure to a 50 Hz electromagnetic field induces activation of the Epstein-Barr virus genome

zondag, 22 maart 2020 - Categorie: Onderzoeken

Bron 1: www.emrsa.co.za/exposure-to-a-50-hz-electromagnetic-field-induces-activation-of-the-epstein-barr-virus-genome-in-latently-infected-human-lymphoid-cells/
sept. 2019

According to the 14th Report on Carcinogens (RoC) released by the USA’s National Toxicology Program (NTP) in Nov 2016, the Epstein Barr virus is now a known human carcinogen based on sufficient evidence from human studies.

They say it is more likely to lead to cancer in people that have weakened immune systems or immunosuppression and given that vaccines are not available, prevention is critical for reducing potential cancer risks.

Epstein-Barr virus: ntp.niehs.nih.gov/ntp/roc/content/profiles/viruses_ebv.pdf



And this study reported that approximately 20% of human cancers is attributable to DNA oncogenic viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV): “DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations” (Jul 2017, Oxid Med Cell Longev.)

Exposure to a 50 Hz electromagnetic field induces activation of the Epstein-Barr virus genome in latently infected human lymphoid cells.

By: Grimaldi S, Pasquali E, Barbatano L, Lisi A, Santoro N, Serafino A, Pozzi D
Published in: J Environ Pathol Toxicol Oncol 1997; 16 (2-3): 205-207

Abstract: The EBV genome in latently infected lymphoid cells offers an opportunity to follow effects on the transcriptional and translational product clearly distinguishable from those of the host cell genome. Exposure of Akata cells, a human lymphoid cell line latently infected by the EBV genome, to a 50 Hz EMF resulted in an increased number of cells expressing the virus early antigens. This finding provides additional evidence that DNA can be modulated by a magnetic field.

Aim: To study the effects of electromagnetic fields on the Epstein-Barr virus replication.

Background: Human B lymphocytes latently infected with the Epstein-Barr virus genome was used as model system to monitor the effect of 50 Hz electromagnetic fields.

Outcome: No statistically significant difference was found in the growth rates of exposed and non-exposed cells. Exposure to 50 Hz electromagnetic field resulted in an increased number of cells expressing the virus antigens (18% activation of the EBV genome compared to 4% in the control cells). This finding provides evidence that DNA can be modulated by a magnetic field.

Wat oudere informatie, maar mogelijk relevant omdat deze studie aantoont dat een elektromagnetisch veld kan leiden tot een toename van het aantal virussen. Hieronder andere artikelen over de mogelijke invloed van LF EMV op virussen. Alles bij elkaar is er maar weinig info en over de invloed van RF EMV nog minder tot niets.

Bron 2: www.ncbi.nlm.nih.gov/pubmed/16342195
Effect of extremely low frequency electromagnetic fields (ELF-EMF) on Kaposi's sarcoma-associated herpes virus in BCBL-1 cells.
Bioelectromagnetics. 2006 Apr;27(3):226-32.

Pica F 1, Serafino A, Divizia M, Donia D, Fraschetti M, Sinibaldi-Salimei P, Giganti MG, Volpi A.

1. Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy. pica@uniroma2.it

Association between extremely low frequency electromagnetic fields (ELF-EMF) and human cancers is controversial, and few studies have been conducted on their influence on oncogenic viruses. We studied the effects of 1 mT, 50 Hz sine waves, applied for 24-72 h, on Kaposi's sarcoma (KS)-associated herpesvirus (KSHV or HHV-8) in BCBL-1, a latently infected primary effusion lymphoma (PEL) cell line. ELF-EMF exposure did not affect the growth and viability of BCBL-1 cells, either stimulated or not with TPA. The total amount of KSHV DNA detected in ELF-EMF exposed cultures not stimulated with TPA did not differ from that of the unexposed controls (P = ns). However, in the presence of TPA stimulation, total KSHV DNA content was found higher in ELF-EMF exposed than in control BCBL-1 cultures (P = .024) at 72 h exposure, but not earlier. Viral DNA increase significantly correlated with increased mean fluorescence intensity/cell for the lytic antigen gp K8.1A/B (P < .01), but not with percentage of gp K8.1A/B-positive cells or of cells containing virions. Viral progeny produced under ELF-EMF exposure consisted mainly of defective viral particles.

Bron 3: link.springer.com/article/10.1134/S000635091506024X
The effect of a low-frequency electromagnetic field on DNA molecules in aqueous solutions
Molecular Biophysics, Published: 18 February 2016

E. E. Tekutskaya, M. G. Barishev & G. P. Ilchenko

Kuban State University, ul. Stavropolskaya 149, Krasnodar, 350040, Russia
Biophysics volume 60, pages913–916(2015)

A chemiluminescence study showed that hepatitis B virus (HBV) and hepatitis C virus (HCV) DNA amplicons are capable of induced radiation when exposed to electromagnetic fields (EMFs) that range from 7.5 to 30 Hz in frequency and from 24 to 40 A/m in field strength. An EMF with a frequency of 9 Hz was shown to exert the greatest effect on aqueous solutions of the hepatitis virus DNA amplicons. The hydration shell of the DNA amplicons was observed to change. The change in the DNA hydration shell on exposure to a low-frequency EMF was presumed to restore hydrogen bonds, to induce crosslinks, and to facilitate DNA repair.

Bron 4: www.emf-portal.org/en/article/962
Can a 50 Hz electromagnetic field influence the preintegrative steps of replication of a murine retrovirus responsible for leukemia/lymphoma?
Bioelectrochem Bioenerg 44: 279-284, 1997

Bron 5: www.emf-portal.org/en/article/2056
Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein.
Bioelectromagnetics 15 (4): 329-336, 1994

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