NTP: Genotoxicity of cell phone RF radiation in rats and mice following subchronic exposure

zaterdag, 26 oktober 2019 - Categorie: Onderzoeken

Full title:
Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure

Bron: www.ncbi.nlm.nih.gov/m/pubmed/31633839/

Smith-Roe SL 1, Wyde ME 1, Stout MD 1, Winters JW 2, Hobbs CA 2, Shepard KG 2, Green AS 2, Kissling GE 3, Shockley KR 3, Tice RR 1, Bucher JR 1, Witt KL 1.

1. Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
2. Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA.
3. Biostatistics and Computational Biology Branch, NIEHS, Research Triangle Park, NC, USA.

Environ Mol Mutagen. 2019 Oct 21. doi: 10.1002/em.22343. (Epub ahead of print)

The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2-year rodent cancer bioassay that included interim assessments of additional animals for genotoxicity endpoints. Male and female Hsd:Sprague Dawley SD rats and B6C3F1/N mice were exposed from gestation day 5 or postnatal day 35, respectively, to code division multiple access (CDMA) or global system for mobile (GSM) modulations over 18 h/day, at 10 min intervals, in reverberation chambers at specific absorption rates (SAR) of 1.5, 3, or 6 W/kg (rats, 900 MHz) or 2.5, 5, or 10 W/kg (mice, 1900 MHz). After 19 (rats) or 14 (mice) weeks of exposure, animals were examined for evidence of RFR-associated genotoxicity using two different measures. Using the alkaline (pH > 13) comet assay, DNA damage was assessed in cells from three brain regions, liver cells, and peripheral blood leukocytes; using the micronucleus assay, chromosomal damage was assessed in immature and mature peripheral blood erythrocytes. Results of the comet assay showed significant increases in DNA damage in the frontal cortex of male mice (both modulations), leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). Increases in DNA damage judged to be equivocal were observed in several other tissues of rats and mice. No significant increases in micronucleated red blood cells were observed in rats or mice. In conclusion, these results suggest that exposure to RFR is associated with an increase in DNA damage.

This article is protected by copyright. All rights reserved.

Full text at journal site:
doi.org/10.1002/em.22343 .

Similar articles

Effect of cell phone radiofrequency radiation on body temperature in rodents: Pilot studies of the National Toxicology Program's reverberation chamber exposure system.
Wyde ME, et al. Bioelectromagnetics. 2018.

Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured human blood cells.
Tice RR, et al. Bioelectromagnetics. 2002.

935 MHz cellular phone radiation. An in vitro study of genotoxicity in human lymphocytes.
Stronati L, et al. Int J Radiat Biol. 2006.

Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies).

Review article
Natl Toxicol Program Tech Rep Ser. 2010.

The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database.
Review article
Sasaki YF, et al. Crit Rev Toxicol. 2000.

For the links to these pblications see the link on top

Lees verder in de categorie Onderzoeken | Terug naar homepage | Lees de introductie