Neurodegenerative diseases and oxidative damage by electron tunneling proteins in mitochondria
dinsdag, 03 september 2019 - Categorie: Onderzoeken
Medical Hypotheses Volume 127, June 2019, Pages 1-4
Medical hypothesis: Neurodegenerative diseases arise from oxidative damage to electron tunneling proteins in mitochondria
Neurodegeneration Therapeutics, Inc., 3050A Berkmar Drive, Charlottesville, VA 22901-3450, United States
Received 3 February 2019, Accepted 27 March 2019
Mitochondria likely arose from serial endosymbiosis by early eukaryotic cells and control electron flow to molecular oxygen to facilitate energy transformation. Mitochondria translate between the quantum and macroscopic worlds and utilize quantum tunneling of electrons to reduce activation energy barriers to electron flow. Electron tunneling has been extensively characterized in Complex I of the electron transport chain. Age-related increases in oxidative damage to these electron tunneling systems may account for decreased energy storage found in aged and neurodegenerative disease tissues, such as those from sufferers of amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). This hypothesis is testable. If correct, this hypothesis supports pre-symptomatic, mitochondrially-directed oxygen free radical scavenging therapies.
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The possible link to EMF was made by www.emraustralia.com.au
Here’s a theory that may account, not just for the origin of neurodegenerative diseases (NDDs), but for how exposure to electromagnetic radiation may be involved.
In a paper published in the journal Medical Hypothesis in June, James Bennet, a specialist in neurodegenerative diseases, put forward the theory that neurodegenerative diseases, such as Amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s, are caused by deficiencies in energy production in the body’s energy factories—the mitochondria.
Free radicals, he says, damage the proteins in mitochondria’s energy transport systems, which damage more of these proteins, and so the process continues.
‘Once a critical level of energy deficiency is reached in neurons that are high-energy cells, they undergo programmed death, leading to NDD’s that affect multiple neuronal populations,’ he says.
A considerable number of studies have shown that exposure to power-frequency magnetic fields is associated with an increase in neurodegenerative diseases. Many other studies have shown that electromagnetic fields increases the production of free radicals that could be causing the damage. Bennet’s hypothesis could be the connection that links them.
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