Occupational exposure to high-frequency EMF and brain tumor risk in the INTEROCC study: ...

zaterdag, 04 augustus 2018 - Categorie: Onderzoeken

Bron: www.sciencedirect.com/science/article/pii/S016041201830196X?via%3Dihub
Environment International
Volume 119, October 2018, Pages 353-365

Occupational exposure to high-frequency electromagnetic fields and brain tumor risk in the INTEROCC study: An individualized assessment approach

Javier Vilaa bc, Michelle, C.Turner abcd, Esther Gracia-Lavedan abc, Jordi Figuerola abc, Joseph Bowman e Laurel Kin clf, Lesley Richards ong, Geza Benk eh, Martine Hours i, Daniel Krewsk id, Dave McLean j, Marie-Elise Paren tk, Siegal Sadetzki lm, Klaus Schlaefer n, Brigitte Schlehofer n, Joachim Schüz o, Jack Siemiatyck ig, Martie van Tongeren pq, Elisabeth Cardis abc, On behalf of the INTEROCC Study Group 1

Received 1 February 2018, Revised 28 June 2018, Accepted 28 June 2018, Available online 8 July 2018.


Evidence on health effects of long-term occupational exposure to high-frequency EMF remains weak

Individualized cumulative occupational RF and IF exposure indices were assigned to study subjects

No clear associations with RF or IF EMF and glioma or meningioma risk were observed

The possible role of RF magnetic fields on brain tumor promotion/progression should be further investigated.


In 2011, the International Agency for Research on Cancer classified radiofrequency (RF) electromagnetic fields (EMF) as possibly carcinogenic to humans (group 2B), although the epidemiological evidence for the association between occupational exposure to RF-EMF and cancer was judged to be inadequate, due in part to limitations in exposure assessment. This study examines the relation between occupational RF and intermediate frequency (IF) EMF exposure and brain tumor (glioma and meningioma) risk in the INTEROCC multinational population-based case-control study (with nearly 4000 cases and over 5000 controls), using a novel exposure assessment approach.

Individual indices of cumulative exposure to RF and IF-EMF (overall and in specific exposure time windows) were assigned to study participants using a source-exposure matrix and detailed interview data on work with or nearby EMF sources. Conditional logistic regression was used to investigate associations with glioma and meningioma risk.

Overall, around 10% of study participants were exposed to RF while only 1% were exposed to IF-EMF. There was no clear evidence for a positive association between RF or IF-EMF and the brain tumors studied, with most results showing either no association or odds ratios (ORs) below 1.0. The largest adjusted ORs were obtained for cumulative exposure to RF magnetic fields (as A/m-years) in the highest exposed category (≥90th percentile) for the most recent exposure time window (1–4 years before the diagnosis or reference date) for both glioma, OR = 1.62 (95% confidence interval (CI): 0.86, 3.01) and meningioma (OR = 1.52, 95% CI: 0.65, 3.55).

Despite the improved exposure assessment approach used in this study, no clear associations were identified. However, the results obtained for recent exposure to RF electric and magnetic fields are suggestive of a potential role in brain tumor promotion/progression and should be further investigated.

Brain cancerEMFIntermediate frequencyRadiofrequencySource-exposure matrixWorkers

These results are in conflict with investigations in which an increased risk for GBM (Glioma) was found:







Furthermore besides brain tumors there also other types of cancer which are on the rise and which not have been investigated in this research.

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