Effect of cell-phone RF on angiogenesis and cell invasion in human head and neck cancer cells

Bron: www.ncbi.nlm.nih.gov/pubmed/29756334
Head Neck. 2018 May 13. doi: 10.1002/hed.25210.(Epub ahead of print)

Effect of cell-phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells.

Alahmad YM 1, Aljaber M 1, Saleh AI 1, Yalcin HC 2, Aboulkassim T 3, Yasmeen A 3, Batist G 3,4, Moustafa AA 1,2,4,5.

1 College of Medicine, Qatar University, Doha, Qatar.
2 Biomedical Research Centre, Qatar University, Doha, Qatar.
3 Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital.
4 Oncology Department, McGill University, Montreal, Quebec, Canada.
5 Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria.

Abstract
BACKGROUND:
Today, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored.

METHODS:
The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes.

RESULTS:
Our data revealed that cell-phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E-cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models.

CONCLUSION:
Our investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation.

© 2018 Wiley Periodicals, Inc.

KEYWORDS:
Erk1/Erk2; angiogenesis; cancer progression; cell invasion; cell phone; radiofrequency



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