StopUMTS Logo
how to get rid of moles 
Zoeken
   
Voorlichting
16/08/18Wifi uitzetten: modems
10/08/18Netkaart hoogspanningslij
Artikelen
18/08/18Check if your mobile phon
18/08/18Eye Damage in the Microwa
17/08/18Monsanto moet 289 miljoen
17/08/18Ware WLAN ein medikament
16/08/18The full story on EMFs: R
11/08/185-10% Elektrosensiblen
Berichten Nederland
17/08/18De volksgezondheid is bli
15/08/18Huisarts ziet aantal stud
06/08/18’Buitengebied Hoogeveen
28/07/18OPEN BRIEF aan KPN en all
23/07/18Bijna 17.000 LTE-antennes
Berichten België
23/07/18Brusselse overheid tekent
16/06/18Scherpenheuvel-Zichem: Be
Berichten Internationaal
15/08/18USA: CDC Finds Brain, Liv
02/08/18Canada: First withdrawal
26/07/18ICNIRP’s public consult
17/07/18Frankrijk: PhoneGate scan
Ervaringen | Appellen/oproepen
29/07/18WMO aanvraag: ervaring
03/07/18Slimme meter ervaring
28/05/18Stralingsarme werkplek
Onderzoeken
18/08/18Exposure of Insects to Ra
04/08/18Occupational exposure to
29/07/18Oxidative stress in elect
Veel gestelde vragen
13/05/17Vakantie? Witte zo
10/07/16Zeven veel gestelde vrage
Juridische informatie
17/07/18De Omgevingswet en elektr
01/06/18Wetgeving hoogspanningsli
15/05/18Brit dad sues Nokia for u
Oproepen
13/08/18Oproep stralingsarme werk
23/07/18Oproep logeeradres Den Ha
29/06/18Tegenlicht wordt 30% geko
Folders
10/09/17Brochures, folders, websi
29/04/16USA: Meer dan 50 tips voo
Briefwisselingen | Archief: 2008, 2005
07/07/18E/mail naar alle raadsled
07/07/18E-mail naar de TV redacti
Illustraties
 Algemeen
 Fotoalbum zendmasten
 Wetenschappelijke illustraties
Leaky Blood Vessels In The Brain May Lead To Alzheimer's {{(the blood-brain barrier)}}    
Ga naar overzicht berichten in: Artikelen

Leaky Blood Vessels In The Brain May Lead To Alzheimer's (the blood-brain barrier)
maandag, 06 maart 2017 - Dossier: Algemeen


Bron: www.npr.org/sections/health-shots/2015/01/23/379192151/leaky-blood-vessels-in-the-brain-may-lead-to-alzheimers?utm_campaign=storyshare&utm_source=facebook.com&utm_medium=social
23 jan. 2017


Researchers appear to have found a new risk factor for Alzheimer's disease: leaky blood vessels.

An MRI study of found those experiencing mild problems with thinking and memory had much leakier blood vessels in the hippocampus. ''This is exactly the area of the brain that is involved with learning and memory,'' says Berislav Zlokovic, the study's senior author and director of the Zilkha Neurogenetic Institute at the University of Southern California.

The study, published in Neuron, also found that blood vessels in the hippocampus tend to become leakier in all people as they age. But the process is accelerated in those likely to develop Alzheimer's or other forms of dementia.

The finding suggests that it may be possible to identify people at risk for Alzheimer's by looking at their blood vessels, says Rod Corriveau , a program director at the National Institute of Neurological Disorders and Stroke, which helped fund the research. The results also suggests that a drug to help the body seal up leaky blood vessels could delay or prevent Alzheimer's and other forms of dementia.

''This study gives patients and families hope for the future, hope that detecting leaky blood vessels early will provide the opportunity to stop dementia before it starts,'' Corriveau says.

The new research grew out of earlier studies of people who died with Alzheimer's disease. ''We were looking at brains from autopsies and it (became) quite apparent that there is a breakdown of the blood-brain barrier,'' Zlokovic says.

The blood-brain barrier is a special layer of cells that normally prevents bacteria and toxins that circulate in the bloodstream from mixing with the fluid that surrounds brain cells. When it breaks down, toxins leak into the fluid that surrounds brain cells and eventually damage or kill the cells.

The autopsy research couldn't show whether the breakdown occurred before or after Alzheimer's appeared. So Zlokovic and his team used a special type of MRI to study the living brains of more than 60 people. The group included both healthy individuals and people with mild cognitive impairment, which can be an early sign of Alzheimer's.

The researchers paid special attention to the hippocampus because it is one of the first brain areas affected by Alzheimer's. And they found that in some regions of the hippocampus, the permeability of the blood-brain barrier was more than 50 percent higher in people with mild cognitive impairment.

The finding could help explain why people with atherosclerosis and other problems with their blood vessels are more likely to develop Alzheimer's, says Corriveaux. ''There's every reason to think that a lot of Alzheimer's disease does involve vascular damage,'' he says.

The study also adds to the evidence that amyloid plaques and the tangles known as tau aren't the only factors that lead to Alzheimer's. There are probably several different paths to dementia, Corriveau says, including one that involves leaky blood vessels.

One important question now is whether it's possible to repair damage to the blood brain barrier. That may be possible using cells known as pericytes, which help prevent blood vessels in the brain from leaking.


Ga terug naar het hoofdmenu
Afdrukken | Vragen | RSS | Disclaimer