StopUMTS Logo
how to get rid of moles 
Zoeken
   
Voorlichting
17/05/18Slimme meter: overheidsre
02/05/18Wet kwaliteit, klachten e
Artikelen
22/05/18Electromagnetic radiation
22/05/18Selected studies on elect
19/05/18Planetary Emergency
15/05/18Pall letter to California
14/05/185G - Advantages - Disadva
13/05/18Shocking analysis of bloo
Berichten Nederland
22/05/18Mobiele telefoons veroorz
22/05/18'Met de huidige insectens
17/05/18Slimme meter: Energie bes
17/05/18LTE in april goed voor 39
16/05/18Explosieve toename van kl
Berichten België
10/05/18Persbericht: Parlementsle
03/05/18Wallonië ziet af van gro
Berichten Internationaal
21/05/18USA: Kalispell School Boa
18/05/18Geschiedenis van de ontwi
11/05/18Cyprus: Derde video om de
05/05/18COMPILATION of measures t
Ervaringen | Appellen/oproepen
29/04/18Huismeting bij een famili
25/04/185 GHz WiFi en hoofdpijn:
23/04/18Nuenenaren massaal ziek d
Onderzoeken
19/05/18The Effect of the Mret Wa
10/05/18Mathematical Structure fo
10/05/18Exposure of Insects to Ra
Veel gestelde vragen
13/05/17Vakantie? Witte zo
10/07/16Zeven veel gestelde vrage
Juridische informatie
15/05/18Brit dad sues Nokia for u
02/03/18Formal Complaint to the E
26/02/185G From Space & Santa Fe
Oproepen
24/05/18Lezing in Westerhoven: Sm
25/04/18Workshop: EHS en omgaan m
19/04/18Lezing: Smartphones, WiFi
Folders
10/09/17Brochures, folders, websi
29/04/16USA: Meer dan 50 tips voo
Briefwisselingen | Archief: 2008, 2005
04/05/18Ingezonden brief (mail) n
29/04/18Mail naar: het kerkbestuu
Illustraties
 Algemeen
 Fotoalbum zendmasten
 Wetenschappelijke illustraties
The brain connected to the immune system    
Ga naar overzicht berichten in: Onderzoeken

The brain connected to the immune system
zondag, 17 april 2016 - Dossier: Algemeen


Bron: www.mast-victims.org/index.php?content=news&action=view&type=newsitem&id=7104
en
news.virginia.edu/illimitable/discovery/theyll-have-rewrite-textbooks
21 maart 2016

They’ll Have to Rewrite the Textbooks


USA

It’s a stunning discovery that overturns decades of textbook teaching: researchers at the School of Medicine have determined that the brain is directly connected to the immune system by vessels previously thought not to exist. “I really did not believe there were structures in the body that we were not aware of. I thought the body was mapped,” said Jonathan Kipnis, a professor in the Department of Neuroscience and director of the University’s Center for Brain Immunology and Glia. How these vessels could have escaped detection when the lymphatic system has been so thoroughly mapped throughout the body is surprising on its own.

But the true significance of the discovery lies in its ramifications for the study and treatment of neurological diseases ranging from autism to Alzheimer’s disease to multiple sclerosis. Kipnis said researchers no longer need to ask questions such as, “How do we study the immune response of the brain?” or “Why do multiple sclerosis patients have immune system attacks?” “Now we can approach this mechanistically — because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,” Kipnis said. “We believe that for every neurological disease that has an immune component to it, these vessels may play a major role.” Kevin Lee, who chairs the Department of Neuroscience, recalled his reaction the first time researchers in Kipnis’ lab shared their basic result with him.

“I just said one sentence: ‘They’ll have to rewrite the textbooks.’ There has never been a lymphatic system for the central nervous system, and it was very clear from that first singular observation — and they’ve done many studies since then to bolster the finding — that it will fundamentally change the way people look at the central nervous system’s relationship with the immune system,” Lee said.

The discovery was made possible by the work of Antoine Louveau, a postdoctoral fellow in Kipnis’ lab. The vessels were detected after Louveau developed a method to mount a mouse’s meninges — the membranes covering the brain — on a single slide so that they could be examined as a whole. After noticing vessel-like patterns in the distribution of immune cells on his slides, he tested for lymphatic vessels and there they were. The impossible existed. “Live imaging of these vessels was crucial to demonstrate their function, and it would not be possible without collaboration with Tajie Harris,” Kipnis noted. Harris is an assistant professor of neuroscience and a member of the Center for Brain Immunology and Glia. Kipnis also saluted
the “phenomenal” surgical skills of Igor Smirnov, a research associate in the Kipnis lab whose work was critical to the imaging success of the study.

The unexpected presence of the lymphatic vessels raises a tremendous number of questions that now need answers, both about the workings of the brain and the diseases that plague it. For example, take Alzheimer’s disease. “In Alzheimer’s, there are accumulations of big protein chunks in the brain,” Kipnis said. “We think they may be accumulating in the brain because they’re not being efficiently removed by these vessels.” He noted that the vessels look different with age, so the role they play in aging is another avenue to explore. And there’s an enormous array of other neurological diseases, from autism to multiple sclerosis, that must be reconsidered in light of the presence of something science insisted did not exist.


Ga terug naar het hoofdmenu
Afdrukken | Vragen | RSS | Disclaimer