StopUMTS Logo
how to get rid of moles 
Zoeken
   
Voorlichting
06/11/17Beschermen tegen de ra
12/10/17Meetspecialisten, meet
Artikelen
18/11/17Vuile stroom (netvervuili
16/11/17ADHD is meer een probleem
16/11/17Mobile phones cause letha
16/11/17Mt Nardi Wildlife Report
15/11/17Cell Phone Headaches –
14/11/1715.000 wetenschappers uit
Berichten Nederland
19/11/17De iPad-school van Mauric
18/11/17KWF collecteert met stral
16/11/17Promotie van een psycholo
16/11/17Toename van klachten in N
14/11/17Aantal antenne-installati
Berichten België
14/11/17Hoe gezond of ongezond is
24/10/17NMBS-baas Sophie Dutordoi
Berichten Internationaal
18/11/17IARC-WHO: Global burden o
18/11/17Duits verbod op 'slimme'
14/11/17De stralingsbelasting en
09/11/17Bill Gates and Steve Jobs
Ervaringen | Appellen/oproepen
17/11/17Alice kan niet tegen stra
12/11/17Afscherming, voor sommige
05/11/17TV met WiFi; een ervaring
Onderzoeken
14/11/17Modeled and Perceived Exp
06/11/17Decreases in sleep durati
25/10/17Radiation from wireless t
Veel gestelde vragen
13/05/17Vakantie? Witte zo
10/07/16Zeven veel gestelde vrage
Juridische informatie
08/11/17InPower Movement: Early r
19/10/17The precautionary princip
11/10/17Telekom warns of (its own
Oproepen
29/11/17Raadsmarkt ZENDMASTEN &
11/11/17Cursus ‘Straling meten
29/10/17Petitie: Geen uitbreiding
Folders
10/09/17Brochures, folders, websi
29/04/16USA: Meer dan 50 tips voo
Briefwisselingen | Archief: 2008, 2005
10/07/17Brief naar de gemeente C.
14/06/17Mail naar 'De Monitor' na
Illustraties
 Algemeen
 Fotoalbum zendmasten
 Wetenschappelijke illustraties
Changing incidence and improved survival of gliomas    
Ga naar overzicht berichten in: Onderzoeken

Changing incidence and improved survival of gliomas
zaterdag, 30 augustus 2014 - Dossier: Algemeen


Bron: www.ejcancer.com/article/S0959-8049%2814%2900718-7/abstract .
24 juni 2014


Vincent K.Y. Hoemail, Jaap C. Reijneveld, Roelien H. Enting, Henri P. Bienfait, Pierre Robe, Brigitta G. Baumert, Otto Visser, On behalf of the Dutch Society for Neuro-Oncology (LWNO)

Received: January 27, 2014; Received in revised form: May 21, 2014; Accepted: May 21, 2014; Published Online: June 24, 2014

Abstract
Background
Tumours of the central nervous system (CNS) represent a relatively rare but serious health burden. This study provides insight into the incidence and survival patterns of gliomas in the Netherlands diagnosed in adult patients during the time period 1989–2010, with a focus on glioblastoma and low-grade gliomas.

Methods
Data on 21,085 gliomas (excluding grade I tumours) were obtained from the Netherlands Cancer Registry, including tumours of the CNS without pathological confirmation. We calculated the age-standardised incidence rates and the estimated annual percentage change (EAPC) for all glioma subtypes. Crude and relative survival rates were estimated using information on the vital status obtained from the Dutch Municipal Personal Records Database.

Results
Incidence of gliomas in adults increased over time, from 4.9 per 100,000 in 1989 to 5.9 in 2010 (EAPC 0.7%, p < 0.001). Two thirds were astrocytoma, 10% oligodendroglioma/oligoastrocytoma, 3% ependymoma and 21% were unspecified. Within the group of astrocytic tumours, the proportion of glioblastoma rose, while the proportion of anaplastic and unspecified astrocytoma decreased. Unspecified neoplasms also decreased, but this was significant only after 2005. Over the course of the study period, glioblastoma patients more often received multimodality treatment with chemotherapy concomitant and adjuvant to radiotherapy. The crude two-year survival rate of glioblastoma patients improved significantly, from 5% in the time period 1989–1994 to 15% in 2006–2010, with median survival increasing from 5.5 to 9 months. The incidence of low-grade gliomas did not change over time. Survival rates for low-grade oligodendroglial and mixed tumours show a modest improvement.

Conclusions
The incidence rate for the total group of gliomas slightly increased, with a decrease of anaplastic and unspecified tumours and an increase of glioblastoma. Following the introduction of combined chemoradiation, two-year survival rates for glioblastoma significantly improved. Survival improved for low-grade gliomas except for low-grade astrocytic tumours.

Keywords:
Glioma, Glioblastoma, Astrocytoma, Oligodendroglioma, Oligoastrocytoma, Ependymoma, Central nervous system, Incidence, Survival


Ga terug naar het hoofdmenu
Afdrukken | Vragen | RSS | Disclaimer