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Extremely low frequency magnetic fields cause oxidative DNA damage in rats. Extremely low frequency magnetic fields cause oxidative DNA damage in rats. Yokus B, Akdag MZ, Dasdag S, Cakir DU, Kizil M. Department of Biochemistry, Faculty of Veterinary Medicine. Purpose: To detect the genotoxic effects of extremely low frequency (ELF) -magnetic fields (MF) on oxidative DNA base modifications 8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde) in rat leucocytes, measured following exposure to ELF-MF. Materials and methods: After exposure to ELF-MF (50 Hz, 100 and 500 muT, for 2 hours/day during 10 months), DNA was extracted, and measurement of DNA lesions was achieved by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Results: Levels of FapyAde, FapyGua and 8OHdG in DNA were increased by both 100 muT and 500 muT ELF-MF as compared to a cage-control and a sham group; however, statistical significance was observed only in the group exposed to 100 muT. Conclusion: This is the first study to report that ELF-MF exposure generates oxidatively induced DNA base modifications which are mutagenic in mammalian cells, such as FapyGua, FapyAde and 8-OH-Gua, in vivo. This may explain previous studies showing DNA damage and genomic instability. These findings support the hypothesis that chronic exposure to 50-Hz MF may be potentially genotoxic. However, the intensity of ELF-MF has an important influence on the extent of DNA damage. PMID: 18979312 PubMed - in process Voor het originele abstract zie: www.ncbi.nlm.nih.gov/pubmed/18979312?dopt=Abstract .
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