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Altered cortical excitability in subjectively electrosensitive patients J Psychosom Res. 2007 Mar;62(3):283-8. Altered cortical excitability in subjectively electrosensitive patients: Results of a pilot study. www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17324677&dopt=Abstract Landgrebe M, Hauser S, Langguth B, Frick U, Hajak G, Eichhammer P. Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Regensburg, Germany. OBJECTIVE: Hypersensitivity to electromagnetic fields is frequently claimed to be linked to a variety of unspecific somatic and/or neuropsychological complaints. Whereas provocation studies often failed to demonstrate a causal relationship between electromagnetic field exposure and symptom formation, neurophysiological examinations highlight baseline deviations in people claiming to be electrosensitive. METHODS: To elucidate a potential role of dysfunctional cortical regulations in mediating hypersensitivity to electromagnetic fields, cortical excitability parameters were measured by transcranial magnetic stimulation in subjectively electrosensitive patients (n=23) and two control groups (n=49) differing in their level of unspecific health complaints. RESULTS: Electrosensitive patients showed reduced intracortical facilitation as compared to both control groups, while motor thresholds and intracortical inhibition were unaffected. CONCLUSIONS: This pilot study gives additional evidence that altered central nervous system function may account for symptom manifestation in subjectively electrosensitive patients as has been postulated for several chronic multisymptom illnesses sharing a similar clustering of symptoms. PMID: 17324677 PubMed - in process
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